Glutarimide
Glutarimide is a type of chemical compound that belongs to the class of organic compounds known as imidazolidines. Glutarimides are derived from glutaric acid and have a five-membered ring structure. They are used in the synthesis of various pharmaceuticals and biologically active compounds.
Structure and Properties[edit | edit source]
Glutarimide has a five-membered ring structure with two nitrogen atoms and three carbon atoms. The molecular formula of glutarimide is C5H7NO2. It is a white crystalline solid at room temperature and is soluble in water, alcohol, and ether.
Synthesis[edit | edit source]
Glutarimide can be synthesized from glutaric acid by dehydration in the presence of phosphorus pentoxide. The reaction proceeds via cyclization to form the five-membered ring structure.
Uses[edit | edit source]
Glutarimide is used as a building block in the synthesis of various pharmaceuticals and biologically active compounds. For example, it is used in the synthesis of thalidomide, a drug used to treat multiple myeloma and erythema nodosum leprosum.
Safety[edit | edit source]
As with all chemicals, proper safety precautions should be taken when handling glutarimide. It can cause irritation to the skin, eyes, and respiratory system if not handled properly.
See Also[edit | edit source]
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Contributors: Prab R. Tumpati, MD