Glycine receptor, alpha 1

Glycine receptor, alpha 1 (also known as GLRA1) is a protein that in humans is encoded by the GLRA1 gene. This protein is a subunit of the glycine receptor, which is a ligand-gated ion channel.

Function

The GLRA1 gene encodes the alpha 1 subunit of the glycine receptor. The glycine receptor is a member of the neurotransmitter gated ion channel protein family. It functions as a pentamer to form a ligand-gated ion channel. The binding of glycine to the receptor increases the chloride conductance and thus produces hyperpolarization (inhibition of the neuron).

Clinical significance

Mutations in this gene cause some forms of hyperekplexia, a neurologic disorder characterized by startle response. The alpha 1 subunit is the primary binding site for the antagonist strychnine.

See also

• Glycine receptor
• Hyperekplexia
• Strychnine

External links

• GeneCards: GLRA1