Pentamer
Pentamer
A pentamer is a molecular complex composed of five subunits. These subunits can be identical or different and are typically arranged in a symmetrical pattern. Pentamers are commonly found in biological systems and play crucial roles in various biochemical processes.
Structure[edit | edit source]
Pentamers exhibit a quaternary structure, which is the arrangement of multiple protein subunits in a multi-subunit complex. The five subunits in a pentamer can be arranged in a ring-like structure, often leading to a symmetrical and stable configuration. This structural arrangement is significant for the function of many proteins and enzymes.
Examples[edit | edit source]
Immunoglobulin M (IgM)[edit | edit source]
Immunoglobulin M (IgM) is a type of antibody that forms a pentameric structure. IgM is the largest antibody in the human body and is primarily involved in the early stages of the immune response. The pentameric form of IgM allows it to effectively bind to antigens and activate the complement system.
Cholera Toxin[edit | edit source]
Cholera toxin is another example of a pentameric structure. It is produced by the bacterium Vibrio cholerae and consists of five B subunits that form a ring. These B subunits bind to the surface of intestinal cells, facilitating the entry of the toxic A subunit into the cells, leading to the symptoms of cholera.
Function[edit | edit source]
Pentamers play various roles in biological systems, including:
- **Signal Transduction**: Pentameric proteins can be involved in transmitting signals across cell membranes.
- **Enzyme Activity**: Some enzymes function as pentamers, where the arrangement of subunits is crucial for their catalytic activity.
- **Structural Support**: Pentameric structures can provide stability and support to larger protein complexes.
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Contributors: Prab R. Tumpati, MD