Glycopeptide
Glycopeptide is a type of peptide that contains one or more carbohydrate residues. Glycopeptides are produced by a variety of organisms, including bacteria, fungi, and mammals, and have a wide range of biological activities.
Structure[edit | edit source]
Glycopeptides are composed of a peptide backbone to which one or more carbohydrate residues are attached. The carbohydrate residues can be simple monosaccharides such as glucose or galactose, or more complex polysaccharides. The peptide backbone can be composed of any combination of the 20 standard amino acids, and the carbohydrate residues can be attached to the peptide backbone at any position.
Biosynthesis[edit | edit source]
The biosynthesis of glycopeptides involves the action of several enzymes. First, the peptide backbone is synthesized by the ribosome. Then, the carbohydrate residues are attached to the peptide backbone by a process called glycosylation. This process involves the action of enzymes called glycosyltransferases, which transfer the carbohydrate residues from a donor molecule to the peptide backbone.
Biological activity[edit | edit source]
Glycopeptides have a wide range of biological activities. Some glycopeptides, such as vancomycin and teicoplanin, are used as antibiotics to treat bacterial infections. Other glycopeptides, such as erythropoietin and thyrotropin, are hormones that regulate various physiological processes. Still other glycopeptides, such as mucins, are involved in cell-cell interactions and the immune response.
Clinical significance[edit | edit source]
Due to their biological activity, glycopeptides have significant clinical significance. Glycopeptide antibiotics are used to treat serious bacterial infections, especially those caused by Gram-positive bacteria. Glycopeptide hormones are used to treat various medical conditions, such as anemia and hypothyroidism. Abnormal glycosylation of glycopeptides can lead to various diseases, such as cancer and autoimmune disorders.
See also[edit | edit source]
- Peptide
- Carbohydrate
- Glycosylation
- Glycosyltransferase
- Vancomycin
- Teicoplanin
- Erythropoietin
- Thyrotropin
- Mucin
- Gram-positive bacteria
| Glycopeptide Resources | |
|---|---|
|
 |
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
