Growth factor-like domain

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The Growth factor-like domain is a structural motif found in various proteins that play crucial roles in cellular signaling and development. This domain is characterized by its ability to interact with specific receptors and modulate downstream signaling pathways.

Structure

The Growth factor-like domain typically consists of a conserved sequence of amino acids that form a distinct three-dimensional structure. This structure allows the domain to bind to its target receptors with high specificity, triggering a cascade of intracellular events.

Function

Proteins containing the Growth factor-like domain are involved in a wide range of biological processes, including cell proliferation, differentiation, and survival. By binding to their respective receptors, these proteins can activate or inhibit signaling pathways that regulate gene expression and cellular behavior.

Examples

One well-known protein that contains the Growth factor-like domain is Insulin-like growth factor 1 (IGF-1), which plays a key role in promoting cell growth and survival. Another example is Epidermal growth factor (EGF), which stimulates cell proliferation and differentiation.

Clinical Relevance

Mutations in genes encoding proteins with the Growth factor-like domain can lead to various diseases and disorders. Dysregulation of growth factor signaling pathways has been implicated in cancer, developmental abnormalities, and metabolic disorders.

See also

• Growth factor signaling pathway
• Receptor tyrosine kinase
• Cell signaling

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