HDAC9
HDAC9 or Histone Deacetylase 9 is a protein that in humans is encoded by the HDAC9 gene. It is part of the histone deacetylase family, which plays a key role in the regulation of eukaryotic gene expression.
Function[edit | edit source]
HDAC9 is a member of the class IIa histone deacetylase family, which is characterized by the presence of a large N-terminal domain. This domain is responsible for the transcriptional repression of genes. HDAC9, like other members of its family, is known to deacetylate histone proteins, which are critical for the condensation of chromosome structures and the regulation of gene expression.
Clinical Significance[edit | edit source]
Alterations in the normal functioning of HDAC9 have been associated with several diseases. For instance, overexpression of HDAC9 has been observed in certain types of cancer, including breast cancer and gastric cancer. In these cases, HDAC9 is believed to promote cancer progression by repressing the transcription of tumor suppressor genes.
In addition, genetic variants of HDAC9 have been linked to an increased risk of stroke, particularly large vessel ischemic stroke. This suggests that HDAC9 could potentially serve as a therapeutic target for the prevention and treatment of stroke.
See Also[edit | edit source]
References[edit | edit source]
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Contributors: Prab R. Tumpati, MD
