HLA-A36

HLA-A36 is a human leukocyte antigen (HLA) serotype within the HLA-A serotype group. The serotype is determined by the antibody recognition of antigen A*36. This broad antigen group is a part of the larger major histocompatibility complex (MHC) class I molecules, which play a crucial role in the immune system's defense against pathogens.

Structure and Function

HLA-A36, like other MHC class I molecules, is a heterodimer consisting of a heavy chain and a light chain, also known as beta-2 microglobulin. The heavy chain is encoded by the HLA-A gene locus, and the light chain is a common component shared by all MHC class I molecules.

The primary function of HLA-A36 is to present peptides derived from the intracellular protein breakdown to cytotoxic T cells. This process is vital for the immune system to recognize and eliminate cells infected with viruses or other pathogens.

Clinical Significance

HLA-A36 has been associated with various diseases, although the exact mechanisms are not fully understood. Some studies suggest a potential role in autoimmune diseases, such as rheumatoid arthritis and type 1 diabetes. Further research is needed to confirm these associations and understand their implications.

See Also

• HLA-A
• Human leukocyte antigen
• Major histocompatibility complex
• Immune system

References

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