HLA-A43

HLA-A43 is a human leukocyte antigen (HLA) serotype within the HLA-A serotype group. The serotype is determined by the antibody recognition of antigen A43. This serotype is a split antigen of the broad antigen HLA-A1, and it is commonly found in populations in West Africa.

Function

HLA-A43 is a protein that in humans is encoded by the HLA-A gene. HLA-A belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail.

Distribution

HLA-A43 is most commonly found in populations in West Africa. It is also found in lower frequencies in other African populations, as well as in some populations in the Middle East and Europe.

Clinical significance

HLA-A43 has been associated with a number of diseases, including autoimmune diseases, infectious diseases, and cancer. However, the exact role of HLA-A43 in these diseases is still not fully understood and is the subject of ongoing research.

See also

• HLA-A
• HLA class I
• Human leukocyte antigen

References

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