HLA-B16

HLA-B16 is a human leukocyte antigen serotype within the HLA-B serotype group. The serotype is determined by the antibody recognition of antigen B16. This serotype is a split antigen of the broad antigen HLA-B8, and it is commonly found in populations in Europe and North America.

Function

HLA-B16 is a protein that in humans is encoded by the HLA-B gene. The protein encoded by this gene is a member of the major histocompatibility complex (MHC) class I molecules, which are responsible for the presentation of foreign antigens to the immune system. This protein plays a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen.

Clinical significance

HLA-B16 has been associated with a number of autoimmune diseases, including rheumatoid arthritis, multiple sclerosis, and type 1 diabetes. It has also been implicated in susceptibility to infectious diseases such as HIV and hepatitis C.

Distribution

HLA-B16 is found at highest frequencies in populations in Europe and North America. It is less common in populations in Asia and Africa.

See also

• HLA-B
• Human leukocyte antigen
• Major histocompatibility complex
• Autoimmune disease

References

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