HLA-B39

HLA-B39 is a human leukocyte antigen serotype within the HLA-B serotype group. The serotype is determined by the antibody recognition of antigens. HLA-B39 is a split antigen of the broad antigen HLA-B16, and it is more common in individuals of Asian descent.

Structure and Function

HLA-B39 is a cell surface protein that plays a crucial role in the regulation of the immune system in humans. It is part of the major histocompatibility complex (MHC) class I molecules, which present peptide antigens to the T cells of the immune system. The specific structure of HLA-B39 allows it to bind to a distinct set of peptides, influencing the immune response to certain pathogens.

Clinical Significance

HLA-B39 has been associated with several autoimmune diseases, including rheumatoid arthritis, ankylosing spondylitis, and psoriasis. It has also been linked to certain infectious diseases, such as tuberculosis and HIV.

Research

Research into HLA-B39 is ongoing, with scientists seeking to understand the precise mechanisms by which this antigen contributes to disease. This research could potentially lead to new treatments for the diseases associated with HLA-B39.

File:HLA-B39.png

Structure of HLA-B39

See Also

• HLA-B
• Human leukocyte antigen
• Major histocompatibility complex
• Autoimmune disease

References

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