HLA-B45

HLA-B45 is a human leukocyte antigen serotype within the HLA-B serotype group. The serotype is determined by the antibody recognition of antigens. HLA-B45 is a split antigen of the broad antigen HLA-B12, and it is more common in individuals of European descent.

Structure and Function

HLA-B45 is a cell surface protein that plays a crucial role in the regulation of the immune system in humans. It is part of the major histocompatibility complex (MHC) class I molecules, which present peptide antigens to the T cells of the immune system. The specific structure of HLA-B45 allows it to bind to a specific set of peptides, influencing the immune response to certain pathogens.

Clinical Significance

HLA-B45 has been associated with various diseases. For instance, it has been linked to a higher susceptibility to rheumatoid arthritis, a chronic inflammatory disorder affecting many joints, including those in the hands and feet. It has also been associated with certain types of cancer, including melanoma and leukemia.

Genetic Diversity and Distribution

HLA-B45 is relatively common in populations of European descent, but it is less common in other populations. This distribution is likely due to the evolutionary pressures of disease exposure and population migration.

See Also

• HLA-B
• Human leukocyte antigen
• Major histocompatibility complex
• Rheumatoid arthritis
• Cancer