HLA-B63

HLA-B

HLA-B63 is an HLA-B serotype. The serotype identifies the gene products (proteins) of the HLA-B*15:03 allele. HLA-B63 is a split antigen of the broad antigen HLA-B15.

Serotype

HLA-B63 is a part of the HLA-B serotype system, which is used to identify specific proteins produced by the HLA-B gene. The HLA-B63 serotype is specifically associated with the HLA-B*15:03 allele.

Genetics

The HLA-B gene is located on the short arm of chromosome 6 at position 6p21.3. The HLA-B63 serotype is a result of the expression of the HLA-B*15:03 allele, which is one of the many alleles of the HLA-B gene.

Function

The HLA-B gene encodes a protein that is a part of the major histocompatibility complex (MHC) class I molecules. These molecules are responsible for presenting peptide fragments derived from intracellular proteins to cytotoxic T cells. This process is crucial for the immune system to recognize and eliminate infected or malignant cells.

Clinical Significance

The presence of specific HLA-B alleles, including HLA-B63, can be associated with certain diseases and conditions. For example, certain HLA-B alleles are known to be linked with autoimmune diseases, drug hypersensitivity reactions, and other immune-related conditions. However, the specific clinical implications of HLA-B63 are not well-documented and require further research.

See Also

• HLA-B
• HLA-B15
• Major histocompatibility complex
• Chromosome 6