HLA-B67

HLA-B67 is a human leukocyte antigen (HLA) serotype. The HLA system is a group of genes that encode for proteins on the surface of cells that are responsible for regulation of the immune system in humans. HLA-B67 is part of the HLA-B locus, a subregion of the HLA complex on chromosome 6.

Function

HLA-B67, like other HLA types, plays a crucial role in the immune system's defense against pathogens. It presents peptides (small proteins) from within the cell to the immune system. If these peptides are foreign (such as viral or bacterial proteins), they trigger an immune response.

Alleles and haplotypes

HLA-B67 is a split antigen of the broad antigen HLA-B15, meaning it is a subtype of HLA-B15. The HLA-B67 serotype is produced by the B*6701 allele.

Clinical significance

HLA-B67 has been associated with a number of diseases, including HIV progression and autoimmune diseases. However, more research is needed to fully understand these associations.

See also

• HLA-B
• HLA-B15
• Human leukocyte antigen

References

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