HLA-Cw1
HLA-Cw1[edit | edit source]
HLA-Cw1 is a specific allele of the HLA-C gene, which is part of the human leukocyte antigen (HLA) system. The HLA system is a crucial component of the immune system, responsible for the regulation of the immune response in humans. HLA-Cw1 is one of the many alleles that encode for the HLA-C protein, a class I surface antigen that presents endogenous peptides to cytotoxic T cells.
Structure and Function[edit | edit source]
HLA-Cw1, like other HLA-C alleles, encodes a protein that is expressed on the surface of almost all nucleated cells. The primary function of HLA-C molecules is to present peptide fragments derived from intracellular proteins to CD8+ T cells. This process is essential for the immune system to recognize and eliminate infected or malignant cells.
The HLA-Cw1 protein is composed of a heavy chain that is non-covalently associated with beta-2 microglobulin. The heavy chain is encoded by the HLA-C gene located on chromosome 6p21.3. The peptide-binding groove of HLA-Cw1 is highly polymorphic, allowing it to bind a diverse array of peptides.
Genetic Variation[edit | edit source]
HLA-Cw1 is one of many alleles of the HLA-C gene. The polymorphism in the HLA-C gene is significant because it contributes to the diversity of the immune response among individuals. This genetic variation is important for the adaptation of the human population to a wide range of pathogens.
Clinical Significance[edit | edit source]
HLA-Cw1, like other HLA alleles, has been studied in the context of transplantation, autoimmune diseases, and infectious diseases. The compatibility of HLA alleles between donor and recipient is crucial for the success of organ and tissue transplants. Mismatches in HLA alleles can lead to transplant rejection.
In autoimmune diseases, certain HLA alleles, including HLA-Cw1, have been associated with susceptibility or resistance to specific conditions. For example, HLA-Cw1 has been studied in relation to psoriasis and ankylosing spondylitis.
Population Distribution[edit | edit source]
The frequency of HLA-Cw1 varies among different populations. Studies of HLA allele frequencies can provide insights into the evolutionary pressures and migration patterns of human populations.
Also see[edit | edit source]
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
