HLA-Cw4

HLA-Cw4 is a specific allele of the Human Leukocyte Antigen (HLA) system, which is a part of the immune system that helps the body distinguish between its own cells and foreign cells. The HLA system is crucial for the body's defense against pathogens and plays a significant role in transplantation medicine.

Function

HLA-Cw4, like other HLA alleles, is involved in the presentation of antigens to the T cells of the immune system. It binds to peptides derived from pathogens and presents them on the surface of cells. This allows T cells to recognize the infected cells and initiate an immune response.

Association with Diseases

HLA-Cw4 has been associated with several autoimmune diseases, including rheumatoid arthritis and psoriasis. It has also been linked to a higher risk of HIV progression. However, the exact mechanisms behind these associations are not fully understood and are the subject of ongoing research.

Genotyping

Genotyping for HLA-Cw4 is typically done using polymerase chain reaction (PCR) techniques. This can be important in the context of transplantation medicine, as matching the HLA types of the donor and recipient can reduce the risk of graft-versus-host disease.

See Also

• HLA-C
• Human Leukocyte Antigen
• Autoimmune diseases
• Transplantation medicine

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