HLA-DR12

HLA-DR12 is a human leukocyte antigen serotype within the HLA-DR serotype group. The serotype is determined by the antibody recognition of alleles at the HLA-DRB1 locus. HLA-DR12 is a split antigen of the broad antigen HLA-DR2, and it is a broad antigen of HLA-DR12.1/DR12.2.

Function

HLA-DR is a MHC class II cell surface receptor encoded by the human leukocyte antigen complex on chromosome 6 region 6p21.31. The complex is a group of genes that code for proteins found on the surface of cells that help the immune system to recognize foreign substances. HLA-DR is an immune response gene.

Clinical significance

HLA-DR12 has been associated with a number of autoimmune diseases including rheumatoid arthritis, multiple sclerosis, and systemic lupus erythematosus. It is also associated with a higher risk of graft-versus-host disease following organ transplantation.

See also

• HLA-DR
• Human leukocyte antigen
• MHC class II

References

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