HLA-DR51

HLA-DR51 is a human leukocyte antigen serotype within the HLA-DR serotype group. The serotype is determined by the antibody recognition of β1 subset of HLA-DR. It is a split antigen of the broad antigen HLA-DR17, and it is a broad antigen of HLA-DR5. HLA-DR51 is associated with certain diseases, including rheumatoid arthritis, systemic lupus erythematosus, and multiple sclerosis.

Structure and Function

HLA-DR51 is a cell surface protein involved in the regulation of the immune system. It is part of the major histocompatibility complex (MHC) class II, which presents antigens to the T cells. The HLA-DR51 molecule is a heterodimer consisting of an alpha (DRA) and a beta chain (DRB), both anchored in the membrane. The beta chain is approximately 26-28 kDa and its gene contains 6 exons. The alpha chain is approximately 33-35 kDa and its gene contains 5 exons.

Disease Associations

HLA-DR51 has been associated with several autoimmune diseases. It is found at a higher frequency in patients with rheumatoid arthritis, systemic lupus erythematosus, and multiple sclerosis. The exact mechanism of how HLA-DR51 contributes to these diseases is not fully understood, but it is believed to involve the presentation of self-antigens to T cells, leading to an autoimmune response.

See Also

• Human leukocyte antigen
• HLA-DR
• Major histocompatibility complex
• Autoimmune disease