HLA-DRB1
HLA-DRB1 is a human gene that provides instructions for making a protein found on the surface of cells. It is part of a family of genes called the human leukocyte antigen (HLA) complex. The HLA complex helps the immune system distinguish the body's own proteins from proteins made by foreign invaders such as viruses and bacteria.
Function[edit | edit source]
The HLA-DRB1 gene belongs to the HLA class II, DR beta chain paralogs. This class II molecule is a heterodimer consisting of an alpha (DRA) and a beta chain (DRB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins.
Clinical significance[edit | edit source]
Certain variations in the HLA-DRB1 gene are associated with an increased risk of developing several autoimmune conditions, including rheumatoid arthritis, type 1 diabetes, and multiple sclerosis.
See also[edit | edit source]
References[edit | edit source]
External links[edit | edit source]
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Contributors: Prab R. Tumpati, MD
