HLA-DRB1

HLA-DRB1 is a human gene that provides instructions for making a protein found on the surface of cells. It is part of a family of genes called the human leukocyte antigen (HLA) complex. The HLA complex helps the immune system distinguish the body's own proteins from proteins made by foreign invaders such as viruses and bacteria.

Function

The HLA-DRB1 gene belongs to the HLA class II, DR beta chain paralogs. This class II molecule is a heterodimer consisting of an alpha (DRA) and a beta chain (DRB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins.

Clinical significance

Certain variations in the HLA-DRB1 gene are associated with an increased risk of developing several autoimmune conditions, including rheumatoid arthritis, type 1 diabetes, and multiple sclerosis.

See also

• Human leukocyte antigen
• Autoimmune disease
• Rheumatoid arthritis
• Type 1 diabetes
• Multiple sclerosis

External links

• HLA-DRB1 at the National Center for Biotechnology Information

HLA-DRB1 Resources
Need Help Finding a Doctor? Need help finding a doctor or specialist anywhere in the world? Explore our world directory. WikiMD's DocFinder can assist you in locating millions of physicians.	Medical Knowledge Access the latest research - Most recent articles Ongoing trials.

Translate to: East Asian 中文, 日本, 한국어, South Asian हिन्दी, Urdu, বাংলা, తెలుగు, தமிழ், ಕನ್ನಡ,
Southeast Asian Indonesian, Vietnamese, Thai, မြန်မာဘာသာ, European español, Deutsch, français, русский, português do Brasil, Italian, polski