HLA-DRB3 (gene)
HLA-DRB3 is a gene that provides instructions for making a protein that plays a critical role in the immune system. HLA-DRB3 is part of a family of genes called the human leukocyte antigen (HLA) complex. The HLA complex helps the immune system distinguish the body's own proteins from proteins made by foreign invaders such as viruses and bacteria.
Structure[edit | edit source]
The HLA-DRB3 gene is located on the short (p) arm of chromosome 6 at position 21. The protein encoded by this gene is a beta subunit of the HLA-DR antigen, which is part of the major histocompatibility complex class II. This protein plays a crucial role in the immune response by presenting peptides derived from extracellular proteins.
Function[edit | edit source]
The HLA-DRB3 gene is primarily responsible for the production of a protein that plays a vital role in the immune system. This protein is a part of the HLA complex, which helps the immune system differentiate the body's own proteins from proteins made by foreign invaders such as viruses and bacteria.
Clinical significance[edit | edit source]
Mutations in the HLA-DRB3 gene have been associated with various autoimmune diseases, including rheumatoid arthritis, systemic lupus erythematosus, and multiple sclerosis.
See also[edit | edit source]
References[edit | edit source]
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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Contributors: Prab R. Tumpati, MD