HLA-DRB5

HLA-DRB5 is a gene that provides instructions for making a protein that plays a critical role in the immune system. The HLA-DRB5 gene is part of a family of genes called the human leukocyte antigen (HLA) complex. The HLA complex helps the immune system distinguish the body's own proteins from proteins made by foreign invaders such as viruses and bacteria.

Function

The HLA-DRB5 gene belongs to the HLA class II, DR beta chain paralogs. This class II molecule is a heterodimer consisting of an alpha (DRA) and a beta chain (DRB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages).

Clinical significance

The HLA-DRB5 gene is associated with the immune response to certain diseases. For example, variations in the HLA-DRB5 gene are associated with an increased risk of multiple sclerosis, a condition characterized by the progressive damage of the nervous system.

See also

• Human leukocyte antigen
• Multiple sclerosis
• Antigen presenting cell

References

HLA-DRB5 Resources
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