HNRNPLL

HNRNPLL (Heterogeneous Nuclear Ribonucleoprotein L Like) is a protein that in humans is encoded by the HNRNPLL gene. This protein is a member of the heterogeneous nuclear ribonucleoprotein (hnRNP) family which is involved in the processing of mRNA.

Function

HNRNPLL is a RNA binding protein that regulates the alternative splicing of several genes involved in the immune system, including the T cell receptor beta chain (TCR-beta) and the Fc receptor IIIB (FcγRIIIB). It is also involved in the regulation of gene expression during the late stages of T cell development.

Clinical significance

Mutations in the HNRNPLL gene have been associated with a variety of diseases, including rheumatoid arthritis, multiple sclerosis, and cancer. In particular, it has been found that the overexpression of HNRNPLL can lead to the development of T-cell lymphoma.

Structure

The HNRNPLL protein consists of several domains, including an RNA recognition motif (RRM) and a hnRNP K homology (KH) domain. These domains allow the protein to bind to specific sequences of RNA and regulate their splicing.

See also

• Heterogeneous nuclear ribonucleoprotein
• Gene expression
• T cell receptor
• Fc receptor
• RNA splicing

References

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