HRAS

HRAS is a gene that belongs to the RAS gene family. The proteins encoded by this gene are involved in cell signal transduction, which is a critical process for the normal functioning of cells. Mutations in this gene can lead to a variety of cancers, including bladder cancer, thyroid cancer, and lung cancer.

Function

The HRAS gene provides instructions for making a protein called H-Ras, which is part of the RAS/MAPK pathway. This pathway helps control cell growth and division, and is involved in the transmission of chemical signals from outside the cell to the cell's nucleus. The H-Ras protein is attached (bound) to the inner surface of the cell's membrane, where it can interact with other proteins and play a role in cell signaling.

Clinical significance

Mutations in the HRAS gene can lead to the production of an altered H-Ras protein that is permanently active, rather than switching on and off in response to cell signals. This can lead to uncontrolled cell division and the development of cancer. HRAS mutations have been found in a variety of cancers, including bladder cancer, thyroid cancer, and lung cancer.

See also

• RAS/MAPK pathway
• Cell signal transduction
• Cancer