Haloprogin

Haloprogin

Haloprogin is an antifungal drug that was previously used to treat skin infections caused by fungi, such as athlete's foot, jock itch, and ringworm. It was sold under the brand name Halotex, but was withdrawn from the market worldwide in 1998 due to the potential for chloracne and other systemic effects.

History

Haloprogin was first synthesized in the 1960s by Upjohn Company, a pharmaceutical company based in the United States. It was marketed as an antifungal agent for topical use, primarily for the treatment of skin infections caused by dermatophytes. However, in 1998, the drug was withdrawn from the market due to concerns about its safety profile.

Pharmacology

Haloprogin is a halogenated phenol, which means it contains a phenol group with one or more halogen atoms attached. It works by inhibiting the growth of fungi, thereby helping to clear up infections. The exact mechanism of action is not fully understood, but it is believed to interfere with the fungal cell membrane, disrupting its function and leading to cell death.

Side Effects

The most common side effects of haloprogin include skin irritation, redness, and swelling at the application site. In rare cases, it can cause more serious side effects such as chloracne, a severe skin condition characterized by acne-like lesions, and systemic effects if absorbed through the skin in large amounts.

Withdrawal from Market

In 1998, haloprogin was withdrawn from the market worldwide. This decision was made due to the potential for serious side effects, including chloracne and other systemic effects. Despite its effectiveness as an antifungal agent, the risks associated with its use were deemed to outweigh the benefits.

See Also

• Antifungal medication
• Dermatophyte
• Phenol

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