Hemin
Hemin is a chemical compound derived from hemoglobin, a protein that carries oxygen in the blood. It is used as a medication to treat certain conditions related to porphyria, a group of rare genetic disorders that affect the nervous system and skin.
Chemical Structure[edit | edit source]
Hemin is an iron-containing porphyrin. It is the protoporphyrin IX containing a ferric iron ion (Fe3+) with a chloride ligand.
Medical Uses[edit | edit source]
Hemin is used to treat acute attacks of certain types of porphyria. These include acute intermittent porphyria, variegate porphyria, and hereditary coproporphyria. It works by reducing the production of porphyrins in the body.
Side Effects[edit | edit source]
Common side effects of hemin include headache, fever, and injection site reactions. Serious side effects may include blood clots and kidney problems.
Pharmacology[edit | edit source]
Hemin works by inhibiting the enzyme ALA synthase, which is involved in the production of porphyrins. This reduces the levels of porphyrins in the body, helping to alleviate the symptoms of porphyria.
History[edit | edit source]
Hemin was first isolated in the 19th century. It was approved for medical use in the United States in 1983.
See Also[edit | edit source]
References[edit | edit source]
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