Hexestrol

Hexestrol is a synthetic, nonsteroidal estrogen that was formerly used for a variety of indications but is no longer marketed due to its potential to cause serious adverse effects. It is a diethylstilbestrol analog.

Medical Uses

Hexestrol was used in the treatment of menopausal symptoms, prostate cancer, and certain other conditions. However, it is no longer used medically due to its association with serious side effects, including an increased risk of cancer and cardiovascular disease.

Pharmacology

Hexestrol is a synthetic, nonsteroidal estrogen of the stilbestrol group that is related to diethylstilbestrol. It has strong estrogenic effects and relatively weak androgenic effects.

Side Effects

The use of hexestrol has been associated with an increased risk of cancer, particularly breast cancer and endometrial cancer. It may also increase the risk of cardiovascular disease, including thrombosis and stroke. Other side effects may include nausea, vomiting, breast tenderness, and menstrual irregularities.

History

Hexestrol was first synthesized in 1939 and was introduced for medical use in the 1940s. It was withdrawn from the market in many countries in the 1970s due to concerns about its safety.

See Also

• Estrogen
• Diethylstilbestrol
• Menopause
• Prostate cancer
• Breast cancer
• Endometrial cancer
• Cardiovascular disease
• Thrombosis
• Stroke

Hexestrol Resources
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