Hexuronic acid

Hexestrol dipropionate is a synthetic, nonsteroidal estrogen that was developed in the 1940s and has been used in hormone therapy. It is a derivative of hexestrol, a potent synthetic estrogen, and is used primarily in the treatment of menopausal symptoms and certain types of breast cancer.

Chemistry

Hexestrol dipropionate is a synthetic estrogen that is structurally related to the natural estrogen, estradiol. It is a dipropionate ester of hexestrol, which means it has two propionate groups attached to the hexestrol molecule. This modification increases the lipophilicity of the drug, which can enhance its absorption and prolong its duration of action.

Pharmacology

Hexestrol dipropionate acts as an agonist of the estrogen receptor, the biological target of estrogens. By binding to the estrogen receptor, it mimics the effects of natural estrogens in the body. This can help to alleviate symptoms of estrogen deficiency, such as hot flashes and vaginal dryness, in menopausal women. In addition, it can inhibit the growth of certain types of breast cancer cells that are sensitive to estrogens.

Clinical use

Hexestrol dipropionate has been used in the treatment of menopausal symptoms and certain types of breast cancer. However, its use has declined in recent years due to the development of newer, safer estrogen therapies. It is generally administered by injection.

Side effects

Like other estrogens, hexestrol dipropionate can cause a range of side effects, including nausea, vomiting, breast tenderness, and menstrual irregularities. It can also increase the risk of certain serious conditions, such as blood clots, stroke, and endometrial cancer.

See also

• Hexestrol
• Estrogen
• Hormone therapy
• Breast cancer