Hidesaburo Hanafusa

Hidesaburo Hanafusa (August 1, 1929 – March 15, 2009) was a prominent Japanese virologist and cancer researcher. He is best known for his groundbreaking work in the field of oncovirology, particularly for his discovery of the src gene and its role in oncogenesis.

Early Life and Education

Hanafusa was born in Hyogo Prefecture, Japan. He completed his undergraduate studies at Osaka University and later pursued his doctoral studies at the same institution, earning a Ph.D. in virology.

Career and Research

Hanafusa began his career at the Rockefeller University in New York, where he worked under the mentorship of renowned virologist Peyton Rous. During his tenure at Rockefeller University, Hanafusa made significant contributions to the understanding of how certain viruses can induce cancer in animals.

Discovery of the src Gene

One of Hanafusa's most notable achievements was the discovery of the src gene, a proto-oncogene that plays a crucial role in the regulation of cell growth and division. His research demonstrated that mutations in the src gene could lead to uncontrolled cell proliferation, a hallmark of cancer. This discovery was pivotal in the field of molecular biology and has had lasting implications for cancer research and treatment.

Later Work

In addition to his work on the src gene, Hanafusa conducted extensive research on retroviruses and their mechanisms of action. He also explored the interactions between viral proteins and host cellular machinery, contributing to a deeper understanding of viral pathogenesis.

Awards and Honors

Hanafusa received numerous accolades for his contributions to science, including the prestigious Albert Lasker Award for Basic Medical Research in 1982. He was also elected to the National Academy of Sciences and the American Academy of Arts and Sciences.

Personal Life

Hanafusa was known for his dedication to his work and his mentorship of young scientists. He passed away on March 15, 2009, leaving behind a legacy of scientific excellence and innovation.

Related Pages

• Oncovirology
• src (gene)
• Retrovirus
• Peyton Rous
• Albert Lasker Award for Basic Medical Research
• Rockefeller University