Histone acetylation

Histamine phosphate is a salt form of histamine, a naturally occurring biogenic amine that plays a crucial role in many biological processes. It is used in various medical and scientific applications.

Chemistry

Histamine phosphate is a monobasic salt formed by the reaction of histamine with phosphoric acid. The chemical formula of histamine phosphate is C5H9N3.2H3PO4. It is a white, crystalline powder that is soluble in water and practically insoluble in ethanol.

Biological Role

Histamine, the parent compound of histamine phosphate, is involved in local immune responses as well as regulating physiological function in the gut and acting as a neurotransmitter. It is produced by basophils and mast cells in nearby connective tissues. Histamine increases the permeability of the capillaries to white blood cells and some proteins, allowing them to engage pathogens in the infected tissues.

Medical Uses

Histamine phosphate is used in medicine for various purposes. It is used as a diagnostic aid for evaluating gastric secretory function. It is also used in allergy testing because it causes vasodilation, contraction of smooth muscle, and increased gastric acid secretion, mimicking the symptoms of an allergic reaction.

Safety

Excessive amounts of histamine can lead to a condition known as histamine poisoning or scombroid food poisoning. This condition is usually associated with the consumption of high-histamine foods, such as certain types of fish and cheese. Symptoms can include flushing, headache, itching, hives, and difficulty breathing.

See Also

• Histamine H1 receptor
• Histamine H2 receptor
• Histamine H3 receptor
• Histamine H4 receptor
• Histamine antagonist