Histone cluster 2 h3 family member d

Histone Cluster 2 H3 Family Member D (HIST2H3D) is a protein coding gene located on human chromosome 1. The protein encoded by this gene is a member of the histone family, which are the primary protein components of chromatin, acting as spools around which DNA winds.

Function

Histones play a central role in gene regulation. Specifically, HIST2H3D is a part of the histone H3 family, which is a component of the nucleosome. The nucleosome is the smallest subunit of chromatin and consists of 147 base pairs of DNA wrapped around an octamer of histone proteins (two each of H2A, H2B, H3, and H4).

Histone proteins, including HIST2H3D, are subject to a range of post-translational modifications, such as methylation, acetylation, and phosphorylation. These modifications alter the physical and chemical properties of the histone, allowing it to play a crucial role in the regulation of gene expression.

Clinical Significance

Alterations in histone modification patterns are a common feature of cancer and are thought to drive disease progression. Mutations in HIST2H3D have been associated with several types of cancer, including glioma, a type of brain cancer.

Research

Research into the role of HIST2H3D in disease is ongoing. Understanding the function of this histone and its role in disease could lead to the development of new therapeutic strategies.

File:Histone H3.3.jpg

Histone H3.3, a variant of histone H3 and similar to HIST2H3D

See Also

• Histone
• Chromatin
• Nucleosome
• Gene regulation
• Post-translational modification
• Glioma

References

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