Homosildenafil

Homosildenafil is a phosphodiesterase type 5 inhibitor (PDE5 inhibitor) and analog of sildenafil, the active ingredient in Viagra. It is categorized as a designer drug and is found in counterfeit erectile dysfunction drugs.

Chemistry

Homosildenafil is structurally similar to sildenafil, differing only by the addition of one methyl group. This minor alteration does not affect the drug's mechanism of action, but it does affect its legal status in many countries.

Mechanism of Action

Like sildenafil, homosildenafil works by inhibiting the enzyme phosphodiesterase type 5 (PDE5). This enzyme is responsible for breaking down cyclic guanosine monophosphate (cGMP), a substance that induces smooth muscle relaxation. By inhibiting PDE5, homosildenafil allows cGMP to accumulate, leading to prolonged smooth muscle relaxation and improved blood flow. This mechanism is what makes homosildenafil effective in treating erectile dysfunction.

Legal Status

Homosildenafil is not approved for use in many countries, including the United States, United Kingdom, and Canada. It is often found in counterfeit erectile dysfunction drugs, which are illegal to sell and purchase. In the United States, homosildenafil is classified as a Schedule I drug under the Controlled Substances Act.

Health Risks

The use of homosildenafil carries several health risks. Because it is often found in counterfeit drugs, the exact dosage and purity of the substance are often unknown, increasing the risk of overdose and adverse reactions. Additionally, like other PDE5 inhibitors, homosildenafil can cause side effects such as headaches, flushing, and vision changes. It can also interact with other medications, particularly nitrates, leading to potentially dangerous drops in blood pressure.

See Also

• Sildenafil
• Phosphodiesterase type 5 inhibitor
• Designer drug
• Erectile dysfunction