IBNtxA
IBNtxA is a chemical compound that is used in scientific research. It is a selective agonist for the melanocortin 4 receptor, which is a G protein-coupled receptor that is expressed in the central nervous system. The melanocortin 4 receptor is involved in regulating food intake and energy homeostasis, and it is a target for the development of drugs for the treatment of obesity and related conditions.
Chemical structure and properties[edit | edit source]
IBNtxA is a peptide that is derived from the natural ligand for the melanocortin 4 receptor, alpha-MSH. It has a molecular weight of approximately 1000 daltons, and it is composed of nine amino acids. The sequence of amino acids in IBNtxA is Ac-Nle-c[Asp-His-DPhe-Arg-Trp-Lys]-NH2.
Pharmacology[edit | edit source]
IBNtxA is a potent and selective agonist for the melanocortin 4 receptor. It has a half-life of approximately 2 hours in the bloodstream, and it is metabolized by proteases in the liver and kidneys. IBNtxA has been shown to reduce food intake and increase energy expenditure in animal models, and it is being investigated for its potential use in the treatment of obesity and related conditions.
Clinical significance[edit | edit source]
The melanocortin 4 receptor is a major regulator of food intake and energy homeostasis, and mutations in the gene that encodes this receptor are associated with severe obesity in humans. Drugs that activate the melanocortin 4 receptor, such as IBNtxA, have the potential to reduce food intake and increase energy expenditure, and they could be used to treat obesity and related conditions. However, the development of such drugs is challenging due to the complexity of the melanocortin system and the potential for side effects.
See also[edit | edit source]
| IBNtxA Resources | |
|---|---|
|
 |
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
