ICAM2

ICAM2 (InterCellular Adhesion Molecule 2) is a protein that in humans is encoded by the ICAM2 gene. It is a member of the immunoglobulin superfamily and is primarily expressed on endothelial cells where it aids in immune response and inflammation.

Structure

ICAM2 is a type of cell adhesion molecule (CAM) that is composed of five immunoglobulin domains, and is anchored into the cell membrane by a transmembrane domain. The extracellular portion of the molecule is made up of the immunoglobulin domains, while the intracellular portion interacts with the cytoskeleton.

Function

ICAM2 plays a crucial role in the immune system by facilitating the migration of leukocytes (white blood cells) to sites of inflammation. It does this by binding to LFA-1, a type of integrin found on the surface of leukocytes. This interaction allows the leukocytes to adhere to the endothelial cells and migrate across the blood vessel wall to the site of inflammation.

Clinical significance

Alterations in the expression of ICAM2 have been associated with a variety of diseases, including cancer, autoimmune diseases, and infectious diseases. For example, increased expression of ICAM2 has been observed in certain types of cancer, suggesting that it may play a role in tumor progression.

See also

• Cell adhesion molecule
• Integrin
• Leukocyte
• Endothelial cell