ICI-204,448

ICI-204,448 is a drug which acts as a potent and selective agonist for the κ-opioid receptor. It has analgesic effects and has been used in scientific research. It was first developed by the pharmaceutical company Imperial Chemical Industries (ICI).

Chemistry[edit | edit source]

ICI-204,448 is a synthetic compound of the benzomorphan class. Benzomorphans are a class of opioids that are structurally distinct from the opioids derived from the opium poppy, such as morphine and codeine. They are characterized by a benzene ring fused to a morphinan skeleton.

Pharmacology[edit | edit source]

As a κ-opioid receptor agonist, ICI-204,448 has the ability to induce analgesic effects. The κ-opioid receptor is one of the three main types of opioid receptors in the body, the others being the μ-opioid receptor and the δ-opioid receptor. Agonists of the κ-opioid receptor can produce analgesia, but they also have a number of other effects, including diuresis, dysphoria, and hallucinations.

Medical Use[edit | edit source]

While ICI-204,448 has been used in scientific research, it is not currently approved for medical use. Its primary use has been in the study of the κ-opioid receptor and the effects of its activation.

See Also[edit | edit source]

ICI-204,448 Resources
Need Help Finding a Doctor? Need help finding a doctor or specialist anywhere in the world? Explore our world directory. WikiMD's DocFinder can assist you in locating millions of physicians.	Medical Knowledge Access the latest research - Most recent articles Ongoing trials.