ID1

ID1 or Inhibitor of DNA binding 1 is a protein that in humans is encoded by the ID1 gene. It is a member of the helix-loop-helix (HLH) transcription factor family, characterized by a conserved HLH domain. This protein acts as a dominant-negative regulator of basic HLH proteins by forming non-functional heterodimers, which inhibits the transcription of certain genes.

Function

ID1 protein is a cellular regulatory protein that can bind to and inhibit the function of DNA-binding proteins. It is involved in various cellular processes, including cell differentiation, cell growth, apoptosis, and immune response. It is also implicated in the regulation of stem cell self-renewal.

Clinical Significance

Alterations in the expression of ID1 have been associated with several diseases. Overexpression of ID1 has been observed in various types of cancer, including breast cancer, prostate cancer, and colorectal cancer. It is believed to promote tumor growth and metastasis by inhibiting cell differentiation and promoting cell proliferation. Conversely, reduced expression of ID1 has been linked to neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease.

Research

Research on ID1 is ongoing, with studies focusing on its role in cancer progression and potential as a therapeutic target. Some studies suggest that inhibiting ID1 could slow down or stop the growth of certain cancers.

See Also

• Inhibitor of DNA binding
• Helix-loop-helix
• Transcription factor
• Cancer
• Neurodegenerative diseases