ID4

ID4 or Inhibitor of DNA binding 4 is a protein that in humans is encoded by the ID4 gene. It is a member of the inhibitor of DNA binding family, members of which are transcriptional regulators that contain a helix-loop-helix (HLH) domain but not a basic domain.

Function

Members of the ID family inhibit the functions of basic helix-loop-helix transcription factors in a dominant-negative manner by suppressing their heterodimerization partners through the HLH domains. This protein may play a role in negatively regulating cell differentiation. A mutation in this gene has been associated with a specific type of adenocarcinoma.

Clinical significance

ID4 has been implicated in various types of cancer, including breast cancer, ovarian cancer, and glioblastoma. It is thought to act as a tumor suppressor in some contexts, but may promote cancer growth in others. The exact mechanisms by which ID4 influences cancer development and progression are still being investigated.

See also

• Inhibitor of DNA binding
• Helix-loop-helix
• Adenocarcinoma
• Tumor suppressor

External links

• ID4 at the National Center for Biotechnology Information