ID4
ID4 or Inhibitor of DNA binding 4 is a protein that in humans is encoded by the ID4 gene. It is a member of the inhibitor of DNA binding family, members of which are transcriptional regulators that contain a helix-loop-helix (HLH) domain but not a basic domain.
Function[edit | edit source]
Members of the ID family inhibit the functions of basic helix-loop-helix transcription factors in a dominant-negative manner by suppressing their heterodimerization partners through the HLH domains. This protein may play a role in negatively regulating cell differentiation. A mutation in this gene has been associated with a specific type of adenocarcinoma.
Clinical significance[edit | edit source]
ID4 has been implicated in various types of cancer, including breast cancer, ovarian cancer, and glioblastoma. It is thought to act as a tumor suppressor in some contexts, but may promote cancer growth in others. The exact mechanisms by which ID4 influences cancer development and progression are still being investigated.
See also[edit | edit source]
References[edit | edit source]
External links[edit | edit source]
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Contributors: Prab R. Tumpati, MD
