IGHA2

Ideogram human chromosome 14

IGHA2

IGHA2 is a gene that encodes for the immunoglobulin heavy constant alpha 2 protein. This protein is a component of the immune system and plays a crucial role in the production of antibodies. The IGHA2 gene is located on chromosome 14 in humans.

Function

The primary function of the IGHA2 gene is to produce the IgA2 antibody, which is a subtype of immunoglobulin A. IgA2 is an important component of the mucosal immune system and provides protection against pathogens at mucosal surfaces such as the respiratory and gastrointestinal tracts.

Structure

The IGHA2 gene consists of multiple exons that encode for the IgA2 protein. The protein structure of IgA2 includes two heavy chains and two light chains, with the heavy chains being encoded by the IGHA2 gene.

Clinical Significance

Mutations or dysregulation of the IGHA2 gene can lead to immunodeficiency disorders or autoimmune diseases. Studies have shown that variations in the IGHA2 gene may be associated with susceptibility to certain infections or inflammatory conditions.

Interactions

The IGHA2 gene interacts with other genes involved in the immune response, such as those encoding for other immunoglobulin subtypes or immune cell receptors. These interactions are essential for the proper functioning of the immune system and the production of effective immune responses.