IL-5
IL-5 is a type of interleukin that is produced by T helper cells and mast cells. It plays a crucial role in stimulating B cell growth and increasing eosinophil activity.
Function[edit | edit source]
IL-5 is primarily involved in the stimulation of B cell growth and the increase in eosinophil activity. It is produced by T helper cells in response to antigen stimulation. IL-5 also stimulates the production of immunoglobulin in B cells and promotes the differentiation of eosinophil precursors into mature eosinophils.
Role in Disease[edit | edit source]
Abnormal levels of IL-5 have been associated with various diseases. High levels of IL-5 are often found in patients with asthma and other allergic diseases. It is also involved in the pathogenesis of eosinophilic esophagitis, a chronic immune system disease.
Therapeutic Use[edit | edit source]
Several drugs that target IL-5 have been developed for the treatment of asthma and other allergic diseases. These include mepolizumab, reslizumab, and benralizumab. These drugs work by blocking the action of IL-5, thereby reducing the number of eosinophils in the blood.
See Also[edit | edit source]
- Interleukin
- T helper cell
- Mast cell
- B cell
- Eosinophil
- Immunoglobulin
- Asthma
- Allergic diseases
- Eosinophilic esophagitis
- Mepolizumab
- Reslizumab
- Benralizumab
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Contributors: Prab R. Tumpati, MD
