IL17A

IL17A‏‎ is a cytokine that is produced by T cells in response to their stimulation by antigen-presenting cells. It is a key player in the immune response, particularly in the defense against bacterial and fungal infections. IL17A‏‎ is also implicated in several autoimmune diseases, including psoriasis, rheumatoid arthritis, and multiple sclerosis.

Function

IL17A‏‎ is a member of the Interleukin-17 family, which consists of six cytokines. It is primarily produced by a subset of T cells known as Th17 cells. The main function of IL17A‏‎ is to stimulate the production of other cytokines and chemokines, which in turn recruit neutrophils and monocytes to the site of infection. This makes IL17A‏‎ a crucial component of the immune response to bacterial and fungal infections.

Role in Disease

Overproduction of IL17A‏‎ has been linked to several autoimmune diseases. In psoriasis, IL17A‏‎ is thought to drive the excessive proliferation of keratinocytes, leading to the characteristic skin lesions. In rheumatoid arthritis, IL17A‏‎ promotes the production of inflammatory mediators that contribute to joint damage. In multiple sclerosis, IL17A‏‎ is believed to play a role in the immune attack on the myelin sheath of neurons.

Therapeutic Target

Given its role in autoimmune diseases, IL17A‏‎ has become a target for therapeutic intervention. Several monoclonal antibodies that neutralize IL17A‏‎ have been developed and approved for the treatment of psoriasis and rheumatoid arthritis. These include secukinumab and ixekizumab, which have shown efficacy in reducing disease symptoms and improving patient quality of life.

See Also

• Interleukin-17 family
• Th17 cells
• Psoriasis
• Rheumatoid arthritis
• Multiple sclerosis