IL17RB

IL17RB is a human gene that encodes for the protein Interleukin 17 receptor B. This protein is a member of the interleukin receptor family and plays a crucial role in mediating the immune response of the body.

Function

The IL17RB gene is responsible for encoding the IL17RB protein, which is a part of the interleukin 17 (IL17) family. This family consists of six ligands (IL17A-F) and five receptors (IL17RA-E). The IL17RB protein specifically binds with the ligands IL17B and IL17E, also known as IL25. This binding initiates a signaling cascade that leads to the activation of the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kB) pathway. This pathway plays a significant role in the regulation of immune responses, including inflammation and the defense against pathogens.

Clinical Significance

Alterations in the IL17RB gene have been associated with several diseases. Overexpression of IL17RB has been observed in various types of cancers, including breast cancer and pancreatic cancer. It has also been linked to allergic diseases such as asthma and atopic dermatitis.

Research

Research is ongoing to understand the exact role of IL17RB in disease progression and to explore potential therapeutic targets. Some studies suggest that blocking IL17RB may be a potential strategy for treating certain types of cancer and allergic diseases.

File:IL17RB Gene Location.png

Location of the IL17RB gene on chromosome 3

See Also

• Interleukin 17
• Interleukin receptor
• NF-kB