IL31RA

IL31RA (Interleukin-31 receptor A) is a protein that in humans is encoded by the IL31RA gene. This receptor is a member of the cytokine receptor family, specifically involved in the signaling and biological activities of Interleukin-31 (IL-31), a cytokine produced by T cells and involved in pro-inflammatory conditions and immune response. IL31RA, in conjunction with the Oncostatin M receptor, forms a functional receptor complex that mediates the effects of IL-31.

Function

IL31RA is primarily known for its role in the signaling pathway of IL-31. Upon binding of IL-31, IL31RA associates with the Oncostatin M receptor to initiate a signaling cascade that involves the activation of JAK/STAT, MAPK, and PI3K/AKT pathways. These pathways contribute to the regulation of immune responses, inflammation, and skin homeostasis. The interaction of IL-31 with its receptor is crucial for the development of various allergic conditions, including atopic dermatitis, asthma, and rhinitis, making it a potential target for therapeutic interventions.

Clinical Significance

The IL31RA receptor has been implicated in the pathogenesis of several inflammatory diseases, particularly those related to the skin and airways. Overexpression or heightened sensitivity to IL-31 has been observed in patients with atopic dermatitis and asthma, suggesting a role in the exacerbation of these conditions. Consequently, targeting IL31RA or its ligand, IL-31, has emerged as a promising strategy in the treatment of these diseases. Therapeutic agents that block the interaction between IL-31 and IL31RA are currently under investigation, with the aim of alleviating symptoms and improving the quality of life for patients with IL-31 mediated conditions.

Genetic Aspects

Variations in the IL31RA gene have been associated with susceptibility to certain allergic conditions. Genetic studies have identified single nucleotide polymorphisms (SNPs) within the IL31RA gene that correlate with increased risk of developing atopic dermatitis and other allergic diseases. These findings underscore the genetic component of immune system regulation and the complex nature of cytokine signaling in allergic responses.

See Also

• Interleukin 31
• Cytokine receptor
• JAK/STAT signaling pathway
• MAPK/ERK pathway
• PI3K/AKT signaling pathway
• Atopic dermatitis
• Asthma