ILF2

ILF2 or Interleukin Enhancer Binding Factor 2 is a protein that in humans is encoded by the ILF2 gene. It is a transcription factor involved in the regulation of interleukin gene expression.

Function

ILF2 is a nuclear protein that forms a complex with ILF3. This complex is a component of the transcription factor complex that participates in the regulation of interleukin 2 gene expression. Studies have suggested that this gene may have a role in the pathogenesis of autoimmune diseases.

Structure

The ILF2 gene is located on the short (p) arm of chromosome 1 at position 36.11, from base pair 27,448,803 to base pair 27,468,673. The ILF2 protein is 525 amino acids long, with a molecular weight of approximately 58 kDa.

Clinical Significance

Alterations in the ILF2 gene have been associated with various diseases. For instance, mutations in this gene have been linked to leukemia and lymphoma. Additionally, overexpression of ILF2 has been observed in several types of cancer, including breast cancer and colorectal cancer.

Research

Research is ongoing to understand the role of ILF2 in disease progression and to explore its potential as a therapeutic target. For example, studies are investigating the role of ILF2 in the immune response and its potential use in immunotherapy.

See Also

• Interleukin
• Transcription factor
• Autoimmune diseases
• Leukemia
• Lymphoma
• Breast cancer
• Colorectal cancer
• Immunotherapy