INO80B (gene)

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INO80B is a gene that encodes a protein involved in chromatin remodeling, a crucial process for the regulation of gene expression. The INO80B protein is a subunit of the INO80 complex, which is an ATP-dependent chromatin remodeling complex. This complex plays a significant role in various cellular processes, including DNA repair, transcription, and replication.

Function

The INO80B protein is essential for the proper functioning of the INO80 complex. It contributes to the complex's ability to remodel chromatin by altering the position of nucleosomes on DNA. This remodeling is necessary for the accessibility of DNA to various transcription factors, DNA polymerases, and other proteins involved in gene expression and DNA replication.

Structure

The INO80 complex is a multi-subunit complex, and INO80B is one of its critical components. The complex also includes other subunits such as INO80, RUVBL1, RUVBL2, and ARP5. The precise structure of the INO80 complex and the specific role of each subunit, including INO80B, are subjects of ongoing research.

Role in Disease

Mutations or dysregulation of the INO80B gene can lead to various diseases, particularly those related to defects in DNA repair and chromatin remodeling. Abnormalities in the INO80 complex have been implicated in certain types of cancer and other genetic disorders.

Research

Research on INO80B and the INO80 complex is ongoing, with studies focusing on understanding the detailed mechanisms of chromatin remodeling and the role of these proteins in health and disease. Advances in this field could lead to new therapeutic strategies for diseases associated with chromatin remodeling defects.

See also

• Chromatin
• Chromatin remodeling
• DNA repair
• Gene expression
• Transcription (biology)
• Replication