IRAK1

IRAK1 or Interleukin-1 receptor-associated kinase 1 is a protein that in humans is encoded by the IRAK1 gene. It is a member of the Interleukin-1 receptor-associated kinases family, which is a group of enzymes that play a key role in the innate immune response to bacteria.

Function

IRAK1 is a serine/threonine-protein kinase that plays a critical role in initiating immune response against foreign pathogens. It acts as a mediator of Toll-like receptor and Interleukin-1 receptor signaling pathways, which are necessary for immune response activation.

Clinical significance

Mutations in the IRAK1 gene have been associated with autoimmune diseases such as Systemic lupus erythematosus and rheumatoid arthritis. In addition, IRAK1 has been implicated in the development of cancer, particularly breast cancer and leukemia.

See also

• Interleukin-1 receptor-associated kinases
• Toll-like receptor
• Innate immune system

External links

• IRAK1 at the National Center for Biotechnology Information

IRAK1 Resources
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