IRX5

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IRX5
Symbol IRX5
HGNC ID 6120
Alternative symbols
Entrez Gene
OMIM
RefSeq
UniProt
Chromosome 16q12.2
Locus supplementary data


IRX5 is a member of the Iroquois homeobox gene family, which plays a crucial role in the development of various tissues and organs in the body. The IRX5 gene is located on chromosome 16 and is involved in the regulation of cell differentiation and proliferation.

Function[edit | edit source]

IRX5 is a transcription factor that is essential for the proper development of the cardiovascular system, central nervous system, and other tissues. It regulates the expression of genes involved in cell cycle control and apoptosis, contributing to the maintenance of tissue homeostasis.

Clinical Significance[edit | edit source]

Mutations or dysregulation of the IRX5 gene have been associated with various congenital disorders and diseases. For instance, alterations in IRX5 expression have been linked to cardiac arrhythmias and congenital heart defects. Additionally, IRX5 has been implicated in the development of certain types of cancer, where it may influence tumor growth and progression.

Research[edit | edit source]

Ongoing research is focused on understanding the precise mechanisms by which IRX5 regulates gene expression and its role in disease pathogenesis. Studies are also exploring the potential of targeting IRX5 for therapeutic interventions in conditions such as heart disease and cancer.

See Also[edit | edit source]

References[edit | edit source]


External Links[edit | edit source]

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Contributors: Prab R. Tumpati, MD