ITGA10

ITGA10 or Integrin Subunit Alpha 10 is a protein that in humans is encoded by the ITGA10 gene. It is a member of the integrin family and is primarily expressed in cartilage tissue.

Function

The ITGA10 gene encodes an integrin alpha chain protein. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. This protein combines with the beta 1 chain (ITGB1) to form a collagen type II binding integrin expressed in cartilage.

Clinical Significance

Mutations in the ITGA10 gene have been associated with various diseases, including osteoarthritis, rheumatoid arthritis, and other joint diseases. Research is ongoing to understand the role of ITGA10 in these conditions and to develop potential therapies.

Structure

The ITGA10 protein is a type of integrin, which are transmembrane receptors that facilitate cell-extracellular matrix adhesion. The protein is composed of an alpha chain and a beta chain, which combine to form a heterodimer. The alpha chain of ITGA10 is encoded by the ITGA10 gene.

Expression

ITGA10 is primarily expressed in cartilage tissue, where it plays a crucial role in cell adhesion, migration, and signaling. It is also found in other tissues, including the lungs, kidneys, and heart.

Research

Research into ITGA10 is ongoing, with studies focusing on its role in disease and potential as a therapeutic target. Current research topics include the role of ITGA10 in osteoarthritis, rheumatoid arthritis, and other joint diseases.