ITGAD

ITGAD (Integrin Subunit Alpha D) is a protein that in humans is encoded by the ITGAD gene. This protein is a member of the integrin family and is primarily expressed in monocytes and granulocytes. It plays a crucial role in the immune system, particularly in the process of leukocyte adhesion and migration.

Function

ITGAD, along with its associated beta 2 subunit, forms a heterodimeric integrin that interacts with various extracellular matrix proteins. These interactions are vital for cell adhesion and migration, processes that are essential for immune response and inflammation. ITGAD is also involved in cell signaling and can activate various intracellular pathways that regulate cell behavior.

Clinical Significance

Alterations in the ITGAD gene have been associated with various diseases. For example, mutations in this gene have been linked to autoimmune diseases such as rheumatoid arthritis and lupus. Additionally, changes in the expression of ITGAD have been observed in certain types of cancer, suggesting a potential role in tumor progression.

Research

Research into ITGAD is ongoing, with scientists seeking to better understand its function and its potential role in disease. This research could potentially lead to new therapeutic strategies for treating diseases associated with alterations in ITGAD.

See Also

• Integrin
• Monocyte
• Granulocyte
• Leukocyte
• Extracellular matrix
• Autoimmune disease
• Rheumatoid arthritis
• Lupus
• Cancer