Ib

Ib - a triphenylmethane-based dye and an inhibitor of nicotinamide adenine dinucleotide phosphate (nadp+) oxidase 4 (nox4), with potential anti-invasive and anti-oxidative activities. Upon administration, imipramine blue (ib) inhibits the activity of nox4 and prevents nox4-mediated cell signaling. This prevents the formation of nox4-mediated reactive oxygen species (ros), abrogates the ros-induced inhibition of protein tyrosine phosphatase (ptp) activation, and induces both g2/m cell cycle arrest and apoptosis. Nox4, an enzyme belonging to the nox family of proteins, promotes the production of ros and plays a key role in the suppression of ptp activation; it is upregulated in a variety of cancers. See imipramine blue

Resources

Latest articles - Ib

• Most recent articles
• Ongoing trials

Source: Data courtesy of the U.S. National Library of Medicine. Since the data might have changed, please query MeSH on Ib for any updates.

‎