Imeglimin
Imeglimin is an experimental drug candidate for the treatment of Type 2 diabetes. It is being developed by Poxel and Sumitomo Dainippon Pharma. Imeglimin works by targeting the mitochondria to enhance glucose-stimulated insulin secretion and insulin sensitivity, and to preserve beta cell mass and function.
Mechanism of action[edit | edit source]
Imeglimin's mechanism of action is unique and it acts on three main target organs involved in glucose regulation: the liver, muscle, and the pancreas. It is the first clinical candidate in a new class of oral anti-diabetic agents, the Glimins. Imeglimin acts on the mitochondria and specifically improves bioenergetics. It enhances glucose-stimulated insulin secretion and insulin sensitivity, and it preserves beta cell mass and function, which allows for sustained glucose lowering effects.
Clinical trials[edit | edit source]
Imeglimin has completed Phase 1 and Phase 2 development in over 1,200 subjects in the U.S., EU and Japan. In the U.S. and EU, Imeglimin has successfully completed Phase 2 development in over 850 patients. In Japan, Imeglimin has completed a Phase 2b clinical trial in 299 treatment-naïve patients and a Phase 3 program is currently ongoing.
References[edit | edit source]
See also[edit | edit source]
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