Integrin alpha X

Integrin alpha X (ITGAX) is a protein that in humans is encoded by the ITGAX gene. It is also commonly referred to as CD11c. This protein is a type of integrin, a large family of proteins that mediate cell-to-cell and cell-to-extracellular matrix interactions.

Function

Integrin alpha X is a receptor for fibrinogen, factor X, and ICAM proteins. It recognizes the sequence G-P-R in fibrinogen. It mediates cell-cell interaction during inflammatory responses. It is especially important in monocyte adhesion and chemotaxis.

Structure

The ITGAX protein is a type I membrane protein found on the surface of cells. It is composed of two subunits, alpha and beta, which combine to form a heterodimer. The alpha X subunit is unique to ITGAX, while the beta subunit is shared with other integrins.

Clinical significance

Alterations in the ITGAX gene have been associated with various diseases, including glomerulonephritis, a type of kidney disease, and leukemia, a type of cancer. It is also involved in the immune response to infections and inflammation.

Research

Research into ITGAX is ongoing, with studies focusing on its role in immune response, cell adhesion, and disease progression. It is also being investigated as a potential target for drug therapies.

See also

• Integrin
• CD11c
• Fibrinogen
• Factor X
• ICAM proteins
• Monocyte
• Chemotaxis
• Glomerulonephritis
• Leukemia