Intepirdine
Intepirdine[edit | edit source]
Intepirdine is a pharmaceutical compound that was investigated for its potential use in the treatment of Alzheimer's disease and other forms of dementia. It is a selective antagonist of the 5-HT6 receptor, a subtype of the serotonin receptor that is primarily expressed in the central nervous system.
Mechanism of Action[edit | edit source]
Intepirdine functions by blocking the 5-HT6 receptor, which is believed to play a role in the regulation of neurotransmitter release, including acetylcholine, dopamine, and glutamate. By inhibiting this receptor, intepirdine was hypothesized to enhance cognitive function and improve memory in patients with Alzheimer's disease.
Clinical Development[edit | edit source]
Intepirdine was initially developed by GlaxoSmithKline and later acquired by Axovant Sciences. It underwent several clinical trials to assess its efficacy and safety in patients with Alzheimer's disease. Despite initial promise, the results of the pivotal phase III trial, known as the MINDSET study, did not demonstrate significant improvement in cognitive function compared to placebo.
Discontinuation[edit | edit source]
Following the disappointing results from the MINDSET study, Axovant Sciences announced the discontinuation of further development of intepirdine for Alzheimer's disease. The decision was based on the lack of efficacy observed in the clinical trials, which did not support the continuation of its development for this indication.
Potential Applications[edit | edit source]
Although intepirdine was not successful in treating Alzheimer's disease, research into 5-HT6 receptor antagonists continues, as they may hold potential for other neurological disorders. The exploration of alternative therapeutic targets and combinations with other treatments remains an area of active investigation.
Related Pages[edit | edit source]
Transform your life with W8MD's budget GLP1 injections from $125 and up biweekly
W8MD offers a medical weight loss program NYC and a clinic to lose weight in Philadelphia. Our W8MD's physician supervised medical weight loss centers in NYC provides expert medical guidance, and offers telemedicine options for convenience.
Why choose W8MD?
- Comprehensive care with FDA-approved weight loss medications including:
- loss injections in NYC both generic and brand names:
- weight loss medications including Phentermine, Qsymia, Contrave, Diethylpropion etc.
- Accept most insurances for visits or discounted self pay cost.
- Generic weight loss injections starting from just $125.00 for the starting dose
- In person weight loss NYC and telemedicine medical weight loss options in New York city available
Book Your Appointment
Start your NYC weight loss journey today at our NYC medical weight loss, and Philadelphia and visit Philadelphia medical weight loss Call (718)946-5500 for NY and 215 676 2334 for PA
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's NYC physician weight loss.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available. Call 718 946 5500.
Advertise on WikiMD
WikiMD's Wellness Encyclopedia |
Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates, categories Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD